Parkin structure and function
نویسندگان
چکیده
منابع مشابه
Parkin structure and function
Mutations in the parkin or PINK1 genes are the leading cause of the autosomal recessive form of Parkinson's disease. The gene products, the E3 ubiquitin ligase parkin and the serine/threonine kinase PINK1, are neuroprotective proteins, which act together in a mitochondrial quality control pathway. Here, we review the structure of parkin and mechanisms of its autoinhibition and function as a ubi...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2015
ISSN: 1742-464X,1742-4658
DOI: 10.1111/febs.13249